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Wissenschaftliches Sekretariat Prof. Mario Bargetzi, Aarau Prof. Clonal evolution in acute lymphoblastic leukemia β new insights via high-throughput sequencing and MRD analyses. Introduction: Within the last 3 decades the knowledge of the history, demographics, immune pathology, clinical presentation and management dramatically have been expanded. Methods: Prospecive registries, guidelines, the characteristics of the disturbed immune response by laboratory and clinical studies and new modalities of management are the main factors of improved knowledges.
Results: The prospective registries of immune thrombocytopenia led to new terminologies. In addition studies of the amount of platlet counts between β K showed that less than 7 percents of individuals developed ITP during further observation times. It was recognized that patients with no or mild bleeding management often do not need active treatment, but these patients have to be strictly followed for improvement of their quality of life.
The guidelines of definitions and managements resulted in more individualized management including the quality of life of the patient. Special considerations of management are needed in hyperactive children, in elderly persons with higher rates of comorbities, in pregnant womem, especially during labor an delivery, and in patients, who need preventive treatment i.