Official websites use. Share sensitive information only on official, secure websites. The most frequent and harmful side effect of childbirth is obstetric haemorrhage. Postpartum haemorrhage PPH remains the primary cause of maternal mortality worldwide. Most PPH-related deaths take place in the first 24 hours of life. It is commonly believed that prompt diagnosis and treatment could avert the majority of PPH-related deaths.
The rapid transition of haemorrhage from the remunerated to the decompensated stage is frequently overlooked. For this reason, anticipation, early detection, and management are crucial to reducing the risk of severe PPH SPPH or improving its clinical outcomes. Third-stage labour is a high-risk period for PPH. Active management of PPH is an effective intervention to lessen the incidence of PPH and has been promoted as a means of lowering fatality rates.
Currently, prostaglandins PGs are advised as a second-line uterotonic medication. Strong uterotonic drugs such as carboprost tromethamine play a physiological role in human parturition, helping to birth the fetus and controlling PPH. Prostaglandins have a major effect on uterine tone, which minimizes blood loss. Their discovery, together with the use of their counterparts as uterotonics, has improved PPH management. In order to assist healthcare professionals in managing PPH promptly and minimizing adverse effects on both the mother and the newborn, this review will describe the causes of the disorder, the strategies that have been tried to treat it, and the role that carboprost plays in preventing it.
Keywords: uterotonics, bleeding in pregnancy, active management of third stage of labour, third stage of labour, haemorrhage in pregnancy. Pregnancy- and childbirth-related deaths are known as maternal deaths. These deaths are seen as preventable and rank among the major public health issues in developing and impoverished countries.
The frequent causes of maternal death are infection, eclampsia, obstructed labour, unsafe abortions, and postpartum haemorrhage PPH. The loss of blood of more than millilitres mL during delivery via the vagina and mL after caesarean delivery is generally referred to as PPH. However, there are differences in definitions, and the diagnosis of PPH is frequently based on imprecise estimations of blood loss. Furthermore, the usual blood loss during birth often surpasses or mL, and the normal increases in plasma volume that happen during pregnancy may conceal signs of haemorrhage or shock from blood loss [ 1 , 2 ].
