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Official websites use. Share sensitive information only on official, secure websites. A large proportion of nursing home NH residents suffer from dementia and effects of conventional anti-dementia drugs on their health is poorly known.
We aimed to investigate the associations between exposure to anti-dementia drugs and mortality among NH residents. This retrospective longitudinal observational study involved French NH and the residents admitted in these facilities since and having major neurocognitive disorder. From their electronic health records, we obtained their age, sex, level of dependency, Charlson comorbidity index, and Mini mental examination score at admission. Exposure to anti-dementia drugs was determined using their prescription into 4 categories: none, exposure to acetylcholinesterase inhibitors AChEI alone, exposure to memantine alone, exposure to AChEI and memantine.
Survival until the end of was studied in the entire cohort by Cox proportional hazards. To alleviate bias related to prescription of anti-dementia drugs, we formed propensity-score matched cohorts for each type of anti-dementia drug exposure, and studied survival by the same method. We studied 25, NH residents with major neurocognitive disorder. Their age at admission was Exposure to anti-dementia drugs occurred in 2, Adjusted hazard ratios for mortality were significantly reduced for these three groups exposed to anti-dementia drugs, as compared to reference group: HR: 0.
Results were consistent in propensity-score matched cohorts. The use of conventional anti-dementia drugs is associated with a lower mortality in nursing home residents with dementia and should be widely used in this population.
All these features are common reasons for admission to nursing homes, and it is estimated that around two-thirds of nursing home residents are affected by neurocognitive diseases. Only a few pharmacological treatments are currently available for M-NCD, and their indication depends on the subtype. No pharmacological treatment is indicated for vascular dementia or frontotemporal dementia.