Official websites use. Share sensitive information only on official, secure websites. Acquired brain injury is an urgent situation that requires rapid diagnosis and treatment. However, these methods are costly and require substantial infrastructure and specialized staff.
Circulatory biomarkers of acute brain injury may help in the management of patients with acute cerebrovascular events and prevent poor outcome and mortality.
The purpose of this review is to provide an overview of the development of potential biomarkers of brain damage to increase diagnostic possibilities. For this purpose, we searched the PubMed database of studies on the diagnostic potential of brain injury biomarkers. We also accessed information from Clinicaltrials. In total, we present 41 proteins, enzymes and hormones that have been considered as biomarkers for brain injury, of which 20 have been studied in clinical trials.
Several microRNAs have also emerged as potential clinical biomarkers for early diagnosis. Combining multiple biomarkers in a panel, along with other parameters, is yielding promising outcomes. According to the WHO, millions of people are diagnosed with acquired brain injury every year.
There were 6. In addition, 1. Diseases caused by brain pathology can be prevented with population-based screening, which allows detection of brain damage at earlier stages, when the prognosis for curative treatment is significantly higher compared to later stages.
