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The identification of sentinel lymph nodes is a valuable oncological method, which aims at mapping lymphatic drainage and has the advantage of correctly staging the disease and assessing prognosis. Lymph node invasion is an important prognostic feature. In colorectal cancer, lymphadenectomy is not influenced by the positive or negative status of the sentinel lymph node.
The identification of lymph nodes with possible invasion by staining the primary tumor with methylene blue can lead to improved staging and management. In other words, the consequent administration of neoadjuvant therapy chemotherapy to the appropriate patients may result in lower recurrence rates.
This is a non-randomized prospective study, in which 26 patients with colon cancer with surgical indication were enrolled. Two types of methods were utilized: in vivo 16 patients and ex vivo 10 patients. Of 18 patients with sentinel lymph nodes identified using dye, routine histological examination detected metastases in 6 In conclusion, further research should be conducted into how the clinical application of sentinel node detection can be employed in colorectal cancer.
Keywords: sentinel lymph node, lymphadenectomy, methylene blue, colorectal cancer, oncology. Colorectal cancer is the third most commonly diagnosed malignancy worldwide, with approximately 1. Lymph node status is the best predictive marker for recurrence and survival in patients with colorectal cancer 2. The main prognostic factor in colorectal cancer is the lymph node stage. Ernest A. Gould introduced for the first time in the sentinel lymph node term, while performing a total parotidectomy for a mixed tumor.