E-mail: karim. Integrin targeted therapies by natural bioactive compounds have attracted attention in the field of oncology and cancer treatment. This study evaluates the potential of phenolic extract from the medicinal herb Ecballium elaterium L.
These observations were associated with the reduction of cell motility and migration velocity as revealed in the Boyden chamber and random motility using two-dimensional assays, respectively. Moreover, PEO specifically targeted these integrins in human microvascular endothelial cells HMEC-1 and dose-dependently blocked the in vitro tubulogenesis. Collectively, these results indicate that PEO holds promise for the development of natural integrin-targeted therapies against fibrosarcoma.
Given its central role in the tumorigenesis process, considerable efforts have been made to develop integrins inhibitors as anticancer drugs.
Natural integrin antagonists have recently been emerged as promising therapeutic opportunities. At this point, many studies have uncovered that disintegrins from snake's and arthropod's venoms, 14 alkaloids, 15 coumarins, 16 flavonoids, 17 stilbenes, secoiridoids, lignans, 18 and terpenoids, 19 among others, could effectively modulate a wide range of integrins, inhibiting thereby the key cancer hallmarks adhesion, migration, proliferation, invasion, angiogenesis and metastasis.
The latter chemical class has received particular attention because of its high antitumor and anti-metastasis activity. The antiproliferative and anticancer activity of terpenoid-monoterpenes i. Ecballium elaterium L. Rich, commonly known as squirting cucumber, is a member of the Cucurbitaceae family, and is traditionally used for the treatment of fever, sinusitis, chronic jaundice, liver cirrhosis, hypertension, rheumatic diseases, nocturia, lumbago and otalgia.
