Both men and women treated with mycophenolate mofetil achieved an improvement in lung function during the study period, but the rate of improvement was significantly lower in men.
Conversely, both male and female participants given placebo in SLS I experienced a decline in percentage predicted FVC, with a greater decline, albeit not significantly, among men. The team then analysed levels of 68 biomarkers in bronchoalveolar lavage samples from participants of SLS I to explore the biological mechanisms behind their findings. They found that men were more likely to have detectable levels of proteins involved in matrix remodelling and fibrosis, whereas women were more likely to have detectable levels of proteins involved in inflammation.
Volkmann and colleagues also looked at the safety profiles of the immunosuppressive therapies, finding that men had a lower frequency of anaemia than women 2. The second study, from Hoffmann-Vold and team, took a closer look at the impact of sex on AEs with ILD therapy, with a specific focus on nintedanib. Participants were treated with nintedanib mg twice daily or placebo.
However, nausea, vomiting and liver enzyme elevations were more common among women, whereas serious AEs were more common among men. News stories are provided by medwireNews, which is an independent medical news service provided by Springer Healthcare Ltd. Lancet Rheumatol ; 4 : eβ Lancet Rheumatol ; 4 : eβ Lancet Rheumatol ; 4 : eβ Author: Claire Barnard. Get the latest headlines β in your specialties of choice β delivered straight to your inbox.
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