Official websites use. Share sensitive information only on official, secure websites. Correspondence: jaime. Pancreatic ductal adenocarcinoma PDAC is one of the tumors with the highest mortality, for which survival has hardly changed in the last 40 years. This high mortality is due to the lack of tests that would allow an early diagnosis and the fact that current treatments are not very effective.
Liquid biopsy LB represents an interesting tool that can help in early diagnosis, treatment selection, disease monitoring, evaluation of the response and prognosis. It is a minimally invasive and risk-free procedure that can detect both the presence of genetic material from the tumor and circulating tumor cells CTCs in the blood and in other bodily fluids, and therefore distantly reflect the global status of the disease.
To improve the prognosis, it is necessary to advance in the development of tools that help us in the early diagnosis, treatment selection, disease monitoring, evaluation of the response and prognosis. Liquid biopsy LB , in its different modalities, represents a particularly interesting tool for these purposes, since it is a minimally invasive and risk-free procedure that can detect both the presence of genetic material from the tumor and circulating tumor cells CTCs in the blood and therefore distantly reflect the global status of the disease.
In fact, unlike what happens with other tumors, its mortality has not been reduced in the last decades. Diverse estimates, based on the analysis of cases of the last 10 years, foresee an annual increase of 0.
Some of the factors that contribute to this high mortality are its insidious onset, with unspecific symptoms, and the lack of diagnostic tests and biomarkers that are sensitive and specific enough to allow its early detection.
