Official websites use. Share sensitive information only on official, secure websites. The aim of this study is to evaluate the effect of ejaculation on serum total, free and complex prostate-specific antigen PSA levels and their effect on biopsy decisions. Our study includes 47 men older than 45 years with symptomatic benign prostatic hyperplasia BPH. Eight patients with similar demographic, and clinical characteristics were chosen as a control group.
With three days of sexual abstinence, blood samples were drawn for the measurement of baseline PSA levels, and then the patients were told to ejaculate.
One, 5, 24 and 72 hours after ejaculation, serum total, free and complexed PSA levels were measured. Serum PSA sampling was performed at the same intervals in the control group without ejaculation.
The mean age of the patients was The mean international prostate symptom scores IPSS were The mean baseline total, free, and complexed PSA values were 1. In the study group, total PSA value was found to be 1. Mean total PSA level rose up to 1. Mean free PSA level rose after the first hour postejaculation to 0. There were no statistically significant changes at the other sampled times as for the total, free or complexed PSA serum levels.
When all three values were considered individually, in only 2. When the PSA value is borderline with respect to biopsy decisions, the effect of ejaculation on serum PSA levels may be clinically important. In these patients, ejaculation must be questioned, and repeated. PSA levels should be evaluated 24 hours after ejaculation. There were no statistically significant changes in the levels of complex PSA values. Further studies are needed to clarify the relationship between complexed PSA and ejaculation.
