Official websites use. Share sensitive information only on official, secure websites. Patients liberated from invasive mechanical ventilation are at risk of extubation failure, including inability to breathe without a tracheal tube airway failure or without mechanical ventilation non-airway failure. We sought to identify respective risk factors for airway failure and non-airway failure following extubation.
The primary endpoint of this prospective, observational, multicenter study in 26 intensive care units was extubation failure, defined as need for reintubation within 48 h following extubation. A multinomial logistic regression model was used to identify risk factors for airway failure and non-airway failure. Between 1 December and 1 May , patients undergoing extubation were enrolled.
The extubation-failure rate was By multivariable analysis, risk factors for extubation failure were either common to airway failure and non-airway failure: intubation for coma OR 4.
Specific risk factors have been identified, allowing us to distinguish between risk of airway failure and non-airway failure. The two conditions will be managed differently, both for prevention and curative strategies.
Registered on 21 May The online version of this article Mechanical ventilation is a life-saving intervention [ 1 ]. In the intensive care unit ICU , the timing of liberation from invasive mechanical ventilation is an important issue for clinicians caring for critically ill intubated patients receiving mechanical ventilation, and differs from the extubation procedure after elective surgery [ 1 ].
